Vaccination With Viral Vectors Expressing Chimeric Hemagglutinin, NP and M1 Antigens Protects Ferrets Against Influenza Virus Challenge

Vaccination With Viral Vectors Expressing Chimeric Hemagglutinin, NP and M1 Antigens Protects Ferrets Against Influenza Virus Challenge

Seasonal influenza viruses cause significant morbidity and mortality in the global population every year. Although seasonal vaccination limits disease, mismatches between the circulating strain and the vaccine strain can severely impair vaccine effectiveness. Because of this, there is an urgent need...

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Bibliographic Details
Main Authors: Meagan McMahon, Guha Asthagiri Arunkumar, Wen-Chun Liu, Daniel Stadlbauer, Randy A. Albrecht, Vincent Pavot, Mario Aramouni, Teresa Lambe, Sarah C. Gilbert, Florian Krammer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
influenza
universal influenza virus vaccine
vectored vaccine
stalk antibodies
CD8 T-cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02005/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02005/full

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