Opposing Roles of Blood-Borne Monocytes and Tissue-Resident Macrophages in Limbal Stem Cell Damage after Ocular Injury

Opposing Roles of Blood-Borne Monocytes and Tissue-Resident Macrophages in Limbal Stem Cell Damage after Ocular Injury

Limbal stem cell (LSC) deficiency is a frequent and severe complication after chemical injury to the eye. Previous studies have assumed this is mediated directly by the caustic agent. Here we show that LSC damage occurs through immune cell mediators, even without direct injury to LSCs. In particular...

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Bibliographic Details
Main Authors: Chengxin Zhou, Fengyang Lei, Mirja Mittermaier, Bruce Ksander, Reza Dana, Claes H. Dohlman, Demetrios G. Vavvas, James Chodosh, Eleftherios I. Paschalis
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
limbal stem cell deficiency
cornea
epithelium
macrophages
monocytes
inflammation
Online Access:https://www.mdpi.com/2073-4409/12/16/2089

Internet

https://www.mdpi.com/2073-4409/12/16/2089

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