Evaluation of β-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity

Evaluation of β-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity

β-Sitosterol (β-Sit) is a dietary phytosterol with demonstrated anticancer activity against a panel of cancers, but its poor solubility in water limits its bioavailability and therapeutic efficacy. In this study, poly(lactide-co-glycolic acid) (PLGA) and block copolymers of poly(et...

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Bibliographic Details
Main Authors: Moses Andima, Gabriella Costabile, Lorenz Isert, Albert J. Ndakala, Solomon Derese, Olivia M. Merkel
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Pharmaceutics
Subjects:
β-Sitosterol
PLGA nanoparticles
PEG-PLA nanoparticles
breast cancer
Online Access:https://www.mdpi.com/1999-4923/10/4/232

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https://www.mdpi.com/1999-4923/10/4/232

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