Theoretical analysis of the stress induced B-Z transition in superhelical DNA.

We present a method to calculate the propensities of regions within a DNA molecule to transition from B-form to Z-form under negative superhelical stresses. We use statistical mechanics to analyze the competition that occurs among all susceptible Z-forming regions at thermodynamic equilibrium in a s...

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Bibliographic Details
Main Authors: Dina Zhabinskaya, Craig J Benham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3024258?pdf=render