Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Abstract IL-11 and IL-6 activate signalling via assembly of the cell surface receptor gp130; however, it is unclear how signals are transmitted across the membrane to instruct cellular responses. Here we solve the cryoEM structure of the IL-11 receptor recognition complex to discover how differences...

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Bibliographic Details
Main Authors: Scott Gardner, Yibo Jin, Paul K. Fyfe, Tomas B. Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46235-6

Internet

https://doi.org/10.1038/s41467-024-46235-6

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