Dominant-negative HNF1α mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D

Dominant-negative HNF1α mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D

Summary: Patients with HNF1A variants may develop liver steatosis, while the underlying mechanism is still unclear. Here, we established a mouse model carrying the dominant-negative HNF1α P291fsinsC mutation (hHNF1Amut/-) and found that the mutant mice developed liver steatosis spontaneously under t...

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Bibliographic Details
Main Authors: Moke Liu, Luna Liu, Honglin Guo, Xiude Fan, Tianbao Liu, Chao Xu, Zhao He, Yongfeng Song, Ling Gao, Shanshan Shao, Jiajun Zhao, Peng Lu
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Molecular physiology
Molecular biology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223020953

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http://www.sciencedirect.com/science/article/pii/S2589004223020953

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