Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model

Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model

Metastatic melanoma portends a poor prognosis and patients may present with multiple, simultaneous tumors. Despite recent advances in systemic immunotherapy, a majority of patients fail to respond, or exhibit lesion-specific responses wherein some metastases respond as others progress within the sam...

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Bibliographic Details
Main Authors: Shuyang S. Qin, Booyeon J. Han, Alyssa Williams, Katherine M. Jackson, Rachel Jewell, Alexander C. Chacon, Edith M. Lord, David C. Linehan, Minsoo Kim, Alexandre Reuben, Scott A. Gerber, Peter A. Prieto
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
tumor microenvironment
tumor heterogeneity
metastatic melanoma
tumor models
immunomodulation
PD-L1
Online Access:https://www.mdpi.com/2072-6694/13/10/2293

Internet

https://www.mdpi.com/2072-6694/13/10/2293

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