A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation

A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation

Mammalian limb development is driven by the integrative input from several signaling pathways; a failure to receive or a misinterpretation of these signals results in skeletal defects. The brachydactylies, a group of overlapping inherited human hand malformation syndromes, are mainly caused by mutat...

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Bibliographic Details
Main Authors: Ondrej Bernatik, Tomasz Radaszkiewicz, Martin Behal, Zankruti Dave, Florian Witte, Annika Mahl, Nicole H. Cernohorsky, Pavel Krejci, Sigmar Stricker, Vitezslav Bryja
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
noggin
Wnt5a
non-canonical Wnt pathways
BMP signaling
brachydactyly
Ror2
Online Access:http://journal.frontiersin.org/article/10.3389/fcell.2017.00047/full

Internet

http://journal.frontiersin.org/article/10.3389/fcell.2017.00047/full

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