Negative regulation of humoral immunity due to interplay between the SLAMF1, SLAMF5, and SLAMF6 receptors

Negative regulation of humoral immunity due to interplay between the SLAMF1, SLAMF5, and SLAMF6 receptors

Whereas the SLAMF-associated protein (SAP) is involved in differentiation of TFH cells and antibody responses, the precise requirements of SLAMF receptors in humoral immune responses are incompletely understood. By analyzing mice with targeted disruptions of the SLAMF1, SLAMF5 and SLAMF6 genes, we f...

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Bibliographic Details
Main Authors: Ninghai eWang, Peter J Halibozek, Burcu eYigit, Hui eZhao, Michael S O'Keeffe, Peter eSage, Arlene eSharpe, Cox eTerhorst
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Immunology
Subjects:
Marginal zone B cells
SLAM family of receptors
SLAM-associated protein (SAP)
Follicular T helper cells
Germinal Center B cells
anti-SLAMF6 mAb
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00158/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00158/full

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