6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 Cells

6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 Cells

Gingerols, the pungent ingredients in ginger, are reported to possess a cholesterol-lowering activity. However, the underlying mechanism remains unclear. The present study was to investigate how 6-gingerol (6-GN), the most abundant gingerol in fresh ginger, regulates hepatic cholesterol metabolism....

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Bibliographic Details
Main Authors: Xiao Li, Jingting Guo, Ning Liang, Xinwei Jiang, Yuan Song, Shiyi Ou, Yunfeng Hu, Rui Jiao, Weibin Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
6-gingerol
cholesterol metabolism
LDLR
cholesterol efflux
ABCA1
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00159/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00159/full

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