ABCB5+ mesenchymal stromal cells therapy protects from hypoxia by restoring Ca2+ homeostasis in vitro and in vivo

ABCB5+ mesenchymal stromal cells therapy protects from hypoxia by restoring Ca2+ homeostasis in vitro and in vivo

Abstract Background Hypoxia in ischemic disease impairs Ca2+ homeostasis and may promote angiogenesis. The therapeutic efficacy of mesenchymal stromal cells (MSCs) in peripheral arterial occlusive disease is well established, yet its influence on cellular Ca2+ homeostasis remains to be elucidated. W...

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Bibliographic Details
Main Authors: Kaixuan Yan, Jiaxing Zheng, Mark Andreas Kluth, Lin Li, Christoph Ganss, Benito Yard, Richard Magdeburg, Markus H. Frank, Prama Pallavi, Michael Keese
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Stem Cell Research & Therapy
Subjects:
Peripheral artery disease
Mesenchymal stromal cells
Stem cell therapy
Hypoxia
Calcium ion
Endothelial cells
Online Access:https://doi.org/10.1186/s13287-022-03228-w

Internet

https://doi.org/10.1186/s13287-022-03228-w

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