Synthesis and Biological Evaluation of Chalconesulfonamides: En Route to Proapoptotic Agents with Antiestrogenic Potency

Synthesis and Biological Evaluation of Chalconesulfonamides: En Route to Proapoptotic Agents with Antiestrogenic Potency

Breast and other estrogen receptor α-positive cancers tend to develop resistance to existing drugs. Chalcone derivatives possess anticancer activity based on their ability to form covalent bonds with targets acting as Michael acceptors. This study aimed to evaluate the anticancer properties of a ser...

Full description

Bibliographic Details
Main Authors: Stepan K. Krymov, Diana I. Salnikova, Lyubov G. Dezhenkova, Fedor B. Bogdanov, Alexander A. Korlyukov, Alexander M. Scherbakov, Andrey E. Shchekotikhin
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Pharmaceuticals
Subjects:
chalcone
sulfonamide
breast cancer
antiproliferative activity
4-hydroxytamoxifen resistance
estrogen receptor α
Online Access:https://www.mdpi.com/1424-8247/17/1/32

Internet

https://www.mdpi.com/1424-8247/17/1/32

Similar Items