RAR Inhibitors Display Photo-Protective and Anti-Inflammatory Effects in A2E Stimulated RPE Cells In Vitro through Non-Specific Modulation of PPAR or RXR Transactivation

RAR Inhibitors Display Photo-Protective and Anti-Inflammatory Effects in A2E Stimulated RPE Cells In Vitro through Non-Specific Modulation of PPAR or RXR Transactivation

<i>N</i>-retinylidene-<i>N</i>-retinylethanolamine (A2E) has been associated with age-related macular degeneration (AMD) physiopathology by inducing cell death, angiogenesis and inflammation in retinal pigmented epithelial (RPE) cells. It was previously thought that the A2E e...

Full description

Bibliographic Details
Main Authors: Valérie Fontaine, Thinhinane Boumedine, Elodie Monteiro, Mylène Fournié, Gendre Gersende, José-Alain Sahel, Serge Picaud, Stanislas Veillet, René Lafont, Mathilde Latil, Pierre J. Dilda, Serge Camelo
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
<i>N</i>-retinylidene-<i>N</i>-retinylethanolamine (A2E)
angiogenesis
inflammation
norbixin
nuclear receptor (NR)
peroxisome proliferator-activated receptor (PPAR)
Online Access:https://www.mdpi.com/1422-0067/25/5/3037

Internet

https://www.mdpi.com/1422-0067/25/5/3037

Similar Items