Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C

Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C

PCSK9 is implicated in familial hypercholesterolemia via targeting the cell surface PCSK9-LDLR complex toward lysosomal degradation. The M2 repeat in the PCSK9’s C-terminal domain is essential for its extracellular function, potentially through its interaction with an unidentified “protein X”. The M...

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Bibliographic Details
Main Authors: Sepideh Mikaeeli, Ali Ben Djoudi Ouadda, Alexandra Evagelidis, Rachid Essalmani, Oscar Henrique Pereira Ramos, Carole Fruchart-Gaillard, Nabil G. Seidah
Format: Article
Language:English
Published: MDPI AG 2024-05-01
Series:Cells
Subjects:
PCSK9
LDLR
HFE
HLA-C
MHC-I
lipid metabolism
Online Access:https://www.mdpi.com/2073-4409/13/10/857

Internet

https://www.mdpi.com/2073-4409/13/10/857

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