Deletion of ER-retention motif on SARS-CoV-2 spike protein reduces cell hybrid during cell–cell fusion

Abstract Background The novel SARS-CoV-2 has quickly become a global pandemic since the first reported case in December 2019, with the virus infecting millions of people to date. The spike (S) protein of the SARS-CoV-2 virus plays a key role in binding to angiotensin-converting enzyme 2 (ACE2), a ho...

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Bibliographic Details
Main Authors: Xuening Wang, Chih-Hsiung Chen, Saiaditya Badeti, Jong Hyun Cho, Alireza Naghizadeh, Ziren Wang, Dongfang Liu
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Cell & Bioscience
Subjects:
Online Access:https://doi.org/10.1186/s13578-021-00626-0