CHIP Haploinsufficiency Exacerbates Hepatic Steatosis via Enhanced TXNIP Expression and Endoplasmic Reticulum Stress Responses

CHIP Haploinsufficiency Exacerbates Hepatic Steatosis via Enhanced TXNIP Expression and Endoplasmic Reticulum Stress Responses

TXNIP is a critical regulator of glucose homeostasis, fatty acid synthesis, and cholesterol accumulation in the liver, and it has been reported that metabolic diseases, such as obesity, atherosclerosis, hyperlipidemia, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD), are associated wit...

Full description

Bibliographic Details
Main Authors: Jung-Hwa Han, Dae-Hwan Nam, Seon-Hui Kim, Ae-Rang Hwang, So-Young Park, Jae Hyang Lim, Chang-Hoon Woo
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Antioxidants
Subjects:
carboxyl terminus of the Hsc70-interacting protein (CHIP)
thioredoxin-interacting protein (TXNIP)
non-alcoholic fatty liver disease (NAFLD)
endoplasmic reticulum (ER) stress
metabolic disease
Online Access:https://www.mdpi.com/2076-3921/12/2/458

Internet

https://www.mdpi.com/2076-3921/12/2/458

Similar Items