CHIP Haploinsufficiency Exacerbates Hepatic Steatosis via Enhanced TXNIP Expression and Endoplasmic Reticulum Stress Responses

CHIP Haploinsufficiency Exacerbates Hepatic Steatosis via Enhanced TXNIP Expression and Endoplasmic Reticulum Stress Responses

TXNIP is a critical regulator of glucose homeostasis, fatty acid synthesis, and cholesterol accumulation in the liver, and it has been reported that metabolic diseases, such as obesity, atherosclerosis, hyperlipidemia, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD), are associated wit...

Full description

Bibliographic Details
Main Authors:	Jung-Hwa Han, Dae-Hwan Nam, Seon-Hui Kim, Ae-Rang Hwang, So-Young Park, Jae Hyang Lim, Chang-Hoon Woo
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	Antioxidants
Subjects:	carboxyl terminus of the Hsc70-interacting protein (CHIP) thioredoxin-interacting protein (TXNIP) non-alcoholic fatty liver disease (NAFLD) endoplasmic reticulum (ER) stress metabolic disease
Online Access:	https://www.mdpi.com/2076-3921/12/2/458

Similar Items

Thioredoxin‐interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress
by: Samuel Lee, et al.
Published: (2014-06-01)

N-Lobe of TXNIP Is Critical in the Allosteric Regulation of NLRP3 via TXNIP Binding
by: Fengyu Cheng, et al.
Published: (2022-06-01)

Thioredoxin-interacting protein in diabetic retinal neurodegeneration: A novel potential therapeutic target for diabetic retinopathy
by: Chengzhi Liu, et al.
Published: (2022-08-01)

Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers
by: Yiting Chen, et al.
Published: (2020-10-01)

O-GlcNacylation Links TxNIP to Inflammasome Activation in Pancreatic β Cells
by: Gaelle Filhoulaud, et al.
Published: (2019-05-01)

Drug D, a Diosgenin Derive, Inhibits L-Arginine-Induced Acute Pancreatitis through Meditating GSDMD in the Endoplasmic Reticulum via the TXNIP/HIF-1α Pathway
by: Cuicui Zhang, et al.
Published: (2022-06-01)

Embryonic Deletion of TXNIP in GABAergic Neurons Enhanced Oxidative Stress in PV+ Interneurons in Primary Somatosensory Cortex of Aging Mice: Relevance to Schizophrenia
by: Ting Xue, et al.
Published: (2022-10-01)

Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage
by: Qing Zhao, et al.
Published: (2017-05-01)

Endoplasmic Reticulum and Mitochondria Contacts Correlate with the Presence and Severity of NASH in Humans
by: Chaonan Jin, et al.
Published: (2022-07-01)

Thioredoxin/Txnip: Redoxisome, As a Redox Switch for the Pathogenesis of Diseases
by: Eiji eYoshihara, et al.
Published: (2014-01-01)

The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson’s Disease Physiopathology
by: Cristine Alves da Costa, et al.
Published: (2020-11-01)

Location matters: the endoplasmic reticulum and protein trafficking in dendrites
by: Omar A Ramírez, et al.
Published: (2011-01-01)

Effects of homocysteine-induced endoplasmic reticulum protein on endoplasmic reticulum stress, autophagy, and neuronal apoptosis following intracerebral hemorrhage
by: Hui Wu, et al.
Published: (2020-12-01)

E3 ligase activity of Carboxyl terminus of Hsc70 interacting protein (CHIP) in Wharton's jelly derived mesenchymal stem cells improves their persistence under hyperglycemic stress and promotes the prophylactic effects against diabetic cardiac damages
by: Ayaz Ali, et al.
Published: (2021-09-01)

Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise
by: Julia eBirk, et al.
Published: (2013-06-01)

Erratum: Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise
by: Julia eBirk, et al.
Published: (2013-11-01)

Vanadium(IV)-Chlorodipicolinate Protects against Hepatic Steatosis by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammation
by: Yuanli Wang, et al.
Published: (2022-05-01)

Endoplasmic Reticulum Stress Signaling and Neuronal Cell Death
by: Adalberto Merighi, et al.
Published: (2022-12-01)

Enhanced Oxidative DNA-Damage in Peritoneal Dialysis Patients via the TXNIP/TRX Axis
by: Tina Oberacker, et al.
Published: (2022-06-01)

The Impact of Glycoengineering on the Endoplasmic Reticulum Quality Control System in Yeasts
by: Mari A. Piirainen, et al.
Published: (2022-06-01)

Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration
by: Sebastián eBernales, et al.
Published: (2012-04-01)

Endoplasmic reticulum-associated degradation of glycoproteins in plants
by: Silvia eHüttner, et al.
Published: (2012-04-01)

Current Status of Endoplasmic Reticulum Stress in Type II Diabetes
by: Sagir Mustapha, et al.
Published: (2021-07-01)

Unfolding the Endoplasmic Reticulum of a Social Amoeba: Dictyostelium discoideum as a New Model for the Study of Endoplasmic Reticulum Stress
by: Eunice Domínguez-Martín, et al.
Published: (2018-06-01)

Mechanisms of Hypercapnia-Induced Endoplasmic Reticulum Dysfunction
by: Vitalii Kryvenko, et al.
Published: (2021-11-01)

Endoplasmic reticulum stress in the pathogenesis of alcoholic liver disease
by: Man Na, et al.
Published: (2023-11-01)

CRELD2, endoplasmic reticulum stress, and human diseases
by: Qin Tang, et al.
Published: (2023-03-01)

Endoplasmic Reticulum Stress Signaling and the Pathogenesis of Hepatocarcinoma
by: Juncheng Wei, et al.
Published: (2021-02-01)

Interactions between endoplasmic reticulum stress and extracellular vesicles in multiple diseases
by: Jingyao Ye, et al.
Published: (2022-08-01)

Endoplasmic Reticulum-Associated Biomarkers for Molecular Phenotyping of Rare Kidney Disease
by: Chuang Li, et al.
Published: (2021-02-01)

The Molecular Biodiversity of Protein Targeting and Protein Transport Related to the Endoplasmic Reticulum
by: Andrea Tirincsi, et al.
Published: (2021-12-01)

The endoplasmic reticulum of trypanosomatids: An unrevealed road for chemotherapy
by: Jana Messias Sandes, et al.
Published: (2022-11-01)

Thioredoxin-1 Protects Spinal Cord from Demyelination Induced by Methamphetamine through Suppressing Endoplasmic Reticulum Stress and Inflammation
by: Lihua Yang, et al.
Published: (2018-02-01)

INVESTIGATION OF ENDOPLASMIC RETICULUM SIGNAL PROTEINS IN CUMULUS CELLS WITH NORMAL,HYPERRESPONSIVE,HYPORESPONSIVE AND POLYCYSTIC OVARY SYNDROMES
by: Bahar KARTAL
Published: (2019-08-01)

Endoplasmic reticulum stress and inflammation in the central nervous system
by: Neil T. Sprenkle, et al.
Published: (2017-05-01)

Thioredoxin-Interacting Protein as a Novel Potential Therapeutic Target in Diabetes Mellitus and Its Underlying Complications
by: Wondafrash DZ, et al.
Published: (2020-01-01)

L-Proline Prevents Endoplasmic Reticulum Stress in Microglial Cells Exposed to L-azetidine-2-carboxylic Acid
by: Jordan Allan Piper, et al.
Published: (2023-06-01)

The Crucial Role of Demannosylating Asparagine-Linked Glycans in ERADicating Misfolded Glycoproteins in the Endoplasmic Reticulum
by: Jianjun Zhang, et al.
Published: (2021-01-01)

Valosin-Containing Protein, a Calcium-Associated ATPase Protein, in Endoplasmic Reticulum and Mitochondrial Function and Its Implications for Diseases
by: Xiaonan Sun, et al.
Published: (2020-05-01)

Slow flow induces endothelial dysfunction by regulating thioredoxin-interacting protein-mediated oxidative metabolism and vascular inflammation
by: Yongshun Wang, et al.
Published: (2022-11-01)