A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling

The PTEN induced putative kinase 1 (PINK1) gene is mutated in patients with hereditary early onset Parkinson's disease (PD). The targets of PINK1 and the mechanisms in PD are still not fully understood. Here, we carried out a high-throughput and unbiased microarray study to identify novel funct...

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Bibliographic Details
Main Authors: M. Priyadarshini, J. Tuimala, Y.C. Chen, P. Panula
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000648