Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B.

Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B.

<h4>Background</h4>We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a perforin-independent manner.<h4>Methodology/principal findings</h4>Optical imaging of uptake kinetics...

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Bibliographic Details
Main Authors: Mathias Gehrmann, Stefan Stangl, Andreas Kirschner, Gemma A Foulds, Wolfgang Sievert, Brigitte T Doss, Axel Walch, Alan G Pockley, Gabriele Multhoff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22829941/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22829941/pdf/?tool=EBI

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