PKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability

PKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability

Abstract Spry2 is a molecular modulator of tyrosine kinase receptor signaling pathways that has cancer-type-specific effects. Mammalian Spry2 protein undergoes tyrosine and serine phosphorylation in response to growth factor stimulation. Spry2 expression is distinctly altered in various cancer types...

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Bibliographic Details
Main Authors: Natalia Martínez, Teresa Gragera, María Pilar de Lucas, Ana Belén Cámara, Alicia Ballester, Berta Anta, Alberto Fernández-Medarde, Tania López-Briones, Judith Ortega, Daniel Peña-Jiménez, Antonio Barbáchano, Ana Montero-Calle, Víctor Cordero, Rodrigo Barderas, Teresa Iglesias, Mónica Yunta, José Luís Oliva, Alberto Muñoz, Eugenio Santos, Natasha Zarich, José M. Rojas-Cabañeros
Format: Article
Language:English
Published: Nature Publishing Group 2023-04-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-023-00465-3

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https://doi.org/10.1038/s41389-023-00465-3

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