Siglecs in Brain Function and Neurological Disorders

Siglecs in Brain Function and Neurological Disorders

Siglecs (Sialic acid-binding immunoglobulin-type lectins) are a I-type lectin that typically binds sialic acid. Siglecs are predominantly expressed in immune cells and generate activating or inhibitory signals. They are also shown to be expressed on the surface of cells in the nervous system and hav...

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Bibliographic Details
Main Authors: Shoib Sarwar Siddiqui, Rachel Matar, Maxime Merheb, Rawad Hodeify, Cijo George Vazhappilly, John Marton, Syed Azharuddin Shamsuddin, Hussain Al Zouabi
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
Siglecs
sialic acid
ganglioside
brain
neurological disorder
myelin
multiple sclerosis
Alzheimer’s disease
microglia
ITIM
ITAM
Online Access:https://www.mdpi.com/2073-4409/8/10/1125

Internet

https://www.mdpi.com/2073-4409/8/10/1125

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