Siglecs in Brain Function and Neurological Disorders
Siglecs (Sialic acid-binding immunoglobulin-type lectins) are a I-type lectin that typically binds sialic acid. Siglecs are predominantly expressed in immune cells and generate activating or inhibitory signals. They are also shown to be expressed on the surface of cells in the nervous system and hav...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/10/1125 |
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| author | Shoib Sarwar Siddiqui Rachel Matar Maxime Merheb Rawad Hodeify Cijo George Vazhappilly John Marton Syed Azharuddin Shamsuddin Hussain Al Zouabi |
| author_facet | Shoib Sarwar Siddiqui Rachel Matar Maxime Merheb Rawad Hodeify Cijo George Vazhappilly John Marton Syed Azharuddin Shamsuddin Hussain Al Zouabi |
| author_sort | Shoib Sarwar Siddiqui |
| collection | DOAJ |
| description | Siglecs (Sialic acid-binding immunoglobulin-type lectins) are a I-type lectin that typically binds sialic acid. Siglecs are predominantly expressed in immune cells and generate activating or inhibitory signals. They are also shown to be expressed on the surface of cells in the nervous system and have been shown to play central roles in neuroinflammation. There has been a plethora of reviews outlining the studies pertaining to Siglecs in immune cells. However, this review aims to compile the articles on the role of Siglecs in brain function and neurological disorders. In humans, the most abundant Siglecs are CD33 (Siglec-3), Siglec-4 (myelin-associated glycoprotein/MAG), and Siglec-11, Whereas in mice the most abundant are Siglec-1 (sialoadhesin), Siglec-2 (CD22), Siglec-E, Siglec-F, and Siglec-H. This review is divided into three parts. Firstly, we discuss the general biological aspects of Siglecs that are expressed in nervous tissue. Secondly, we discuss about the role of Siglecs in brain function and molecular mechanism for their function. Finally, we collate the available information on Siglecs and neurological disorders. It is intriguing to study this family of proteins in neurological disorders because they carry immunoinhibitory and immunoactivating motifs that can be vital in neuroinflammation. |
| first_indexed | 2024-03-12T08:13:10Z |
| format | Article |
| id | doaj.art-bbe64837c7e245c18c5b8e225e7286e7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:13:10Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-bbe64837c7e245c18c5b8e225e7286e72023-09-02T19:04:34ZengMDPI AGCells2073-44092019-09-01810112510.3390/cells8101125cells8101125Siglecs in Brain Function and Neurological DisordersShoib Sarwar Siddiqui0Rachel Matar1Maxime Merheb2Rawad Hodeify3Cijo George Vazhappilly4John Marton5Syed Azharuddin Shamsuddin6Hussain Al Zouabi7Department of Biotechnology, American University of Ras Al Khaimah (AURAK), Ras Al Khaimah 10021, UAEDepartment of Biotechnology, American University of Ras Al Khaimah (AURAK), Ras Al Khaimah 10021, UAEDepartment of Biotechnology, American University of Ras Al Khaimah (AURAK), Ras Al Khaimah 10021, UAEDepartment of Biotechnology, American University of Ras Al Khaimah (AURAK), Ras Al Khaimah 10021, UAEDepartment of Biotechnology, American University of Ras Al Khaimah (AURAK), Ras Al Khaimah 10021, UAEDepartment of Biotechnology, American University of Ras Al Khaimah (AURAK), Ras Al Khaimah 10021, UAEDepartment of Biotechnology, American University of Ras Al Khaimah (AURAK), Ras Al Khaimah 10021, UAEDepartment of Biotechnology, American University of Ras Al Khaimah (AURAK), Ras Al Khaimah 10021, UAESiglecs (Sialic acid-binding immunoglobulin-type lectins) are a I-type lectin that typically binds sialic acid. Siglecs are predominantly expressed in immune cells and generate activating or inhibitory signals. They are also shown to be expressed on the surface of cells in the nervous system and have been shown to play central roles in neuroinflammation. There has been a plethora of reviews outlining the studies pertaining to Siglecs in immune cells. However, this review aims to compile the articles on the role of Siglecs in brain function and neurological disorders. In humans, the most abundant Siglecs are CD33 (Siglec-3), Siglec-4 (myelin-associated glycoprotein/MAG), and Siglec-11, Whereas in mice the most abundant are Siglec-1 (sialoadhesin), Siglec-2 (CD22), Siglec-E, Siglec-F, and Siglec-H. This review is divided into three parts. Firstly, we discuss the general biological aspects of Siglecs that are expressed in nervous tissue. Secondly, we discuss about the role of Siglecs in brain function and molecular mechanism for their function. Finally, we collate the available information on Siglecs and neurological disorders. It is intriguing to study this family of proteins in neurological disorders because they carry immunoinhibitory and immunoactivating motifs that can be vital in neuroinflammation.https://www.mdpi.com/2073-4409/8/10/1125Siglecssialic acidgangliosidebrainneurological disordermyelinmultiple sclerosisAlzheimer’s diseasemicrogliaITIMITAM |
| spellingShingle | Shoib Sarwar Siddiqui Rachel Matar Maxime Merheb Rawad Hodeify Cijo George Vazhappilly John Marton Syed Azharuddin Shamsuddin Hussain Al Zouabi Siglecs in Brain Function and Neurological Disorders Cells Siglecs sialic acid ganglioside brain neurological disorder myelin multiple sclerosis Alzheimer’s disease microglia ITIM ITAM |
| title | Siglecs in Brain Function and Neurological Disorders |
| title_full | Siglecs in Brain Function and Neurological Disorders |
| title_fullStr | Siglecs in Brain Function and Neurological Disorders |
| title_full_unstemmed | Siglecs in Brain Function and Neurological Disorders |
| title_short | Siglecs in Brain Function and Neurological Disorders |
| title_sort | siglecs in brain function and neurological disorders |
| topic | Siglecs sialic acid ganglioside brain neurological disorder myelin multiple sclerosis Alzheimer’s disease microglia ITIM ITAM |
| url | https://www.mdpi.com/2073-4409/8/10/1125 |
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