Mutational analysis of the Notch2 negative regulatory region identifies key structural elements for mechanical stability

Mutational analysis of the Notch2 negative regulatory region identifies key structural elements for mechanical stability

The Notch signalling pathway is fundamental to cell differentiation in developing and self‐renewing tissues. Notch is activated upon ligand‐induced conformational change of the Notch negative regulatory region (NRR), unmasking a key proteolytic site (S2) and facilitating downstream events. The favou...

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Bibliographic Details
Main Authors: Natalie L. Stephenson, Johanna M. Avis
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:FEBS Open Bio
Subjects:
Notch
Negative regulatory region
Heterodimerization domain
HD domain
Atomic force microscopy
Molecular dynamics simulations
Online Access:https://doi.org/10.1016/j.fob.2015.07.006

Internet

https://doi.org/10.1016/j.fob.2015.07.006

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