Mutational analysis of the Notch2 negative regulatory region identifies key structural elements for mechanical stability
The Notch signalling pathway is fundamental to cell differentiation in developing and self‐renewing tissues. Notch is activated upon ligand‐induced conformational change of the Notch negative regulatory region (NRR), unmasking a key proteolytic site (S2) and facilitating downstream events. The favou...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.fob.2015.07.006 |