Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis

Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis

Objective: The objective of our study is to investigate the Fc glycosylation profiles of both antigen-specific IgG targeted against proteinase 3 (PR3-ANCA) and total IgG as prognostic markers of relapse in patients with Granulomatosis with Polyangiitis (GPA). Methods: Seventy-five patients with GPA...

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Bibliographic Details
Main Authors: Michael J. Kemna, Rosina Plomp, Pieter van Paassen, Carolien A.M. Koeleman, Bas C. Jansen, Jan G.M.C. Damoiseaux, Jan Willem Cohen Tervaert, Manfred Wuhrer
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:EBioMedicine
Subjects:
PR3-ANCA associated vasculitis
Granulomatosis with Polyangiitis
Glycosylation
Glycopeptide
Immunoglobulin
Mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417300373

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http://www.sciencedirect.com/science/article/pii/S2352396417300373

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