Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma

Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma

Abstract In IDH-mutant astrocytoma, IDH2 mutation is quite rare and biological mechanisms underlying tumor progression in IDH2-mutant astrocytoma remain elusive. Here, we report a unique case of IDH2 mutant astrocytoma, CNS WHO grade 3 that developed tumor progression. We performed a comprehensive g...

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Bibliographic Details
Main Authors: Kensuke Tateishi, Yohei Miyake, Taishi Nakamura, Hiromichi Iwashita, Takahiro Hayashi, Akito Oshima, Hirokuni Honma, Hiroaki Hayashi, Kyoka Sugino, Miyui Kato, Kaishi Satomi, Satoshi Fujii, Takashi Komori, Tetsuya Yamamoto, Daniel P. Cahill, Hiroaki Wakimoto
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Acta Neuropathologica Communications
Subjects:
IDH2 mutation
Astrocytoma
Malignant phenotype
PDX
Online Access:https://doi.org/10.1186/s40478-023-01683-x

Internet

https://doi.org/10.1186/s40478-023-01683-x

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