In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice

In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice

Oxidative stress contributes to the progression of acute liver failure (ALF). Transcription factor nuclear factor-erythroid 2-related factor (Nrf2) serves as an endogenous regulator by which cells combat oxidative stress. We have investigated liver damage and the balance between death and survival s...

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Bibliographic Details
Main Authors: Águeda González-Rodríguez, Bjorn Reibert, Thomas Amann, Rainier Constien, Cristina M. Rondinone, Ángela M. Valverde
Format: Article
Language:English
Published: The Company of Biologists 2014-09-01
Series:Disease Models & Mechanisms
Subjects:
Keap1
Nrf2
Acute liver failure
Apoptosis
In vivo siRNA
Online Access:http://dmm.biologists.org/content/7/9/1093

Internet

http://dmm.biologists.org/content/7/9/1093

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