Discovery of Novel Coumarin-Schiff Base Hybrids as Potential Acetylcholinesterase Inhibitors: Design, Synthesis, Enzyme Inhibition, and Computational Studies

Discovery of Novel Coumarin-Schiff Base Hybrids as Potential Acetylcholinesterase Inhibitors: Design, Synthesis, Enzyme Inhibition, and Computational Studies

To discover anti-acetylcholinesterase agents for the treatment of Alzheimer’s disease (AD), a series of novel Schiff base-coumarin hybrids was rationally designed, synthesized successfully, and structurally characterized using Fourier transform infrared (FTIR), Nuclear magnetic resonance (NMR), and...

Full description

Bibliographic Details
Main Authors: Aso Hameed Hasan, Faruq Azeez Abdulrahman, Ahmad J. Obaidullah, Hadil Faris Alotaibi, Mohammed M. Alanazi, Mahmoud A. Noamaan, Sankaranarayanan Murugesan, Syazwani Itri Amran, Ajmal R. Bhat, Joazaizulfazli Jamalis
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceuticals
Subjects:
acetylcholinesterase
Schiff base
coumarin
DFT
chemical reactivity
molecular modeling
Online Access:https://www.mdpi.com/1424-8247/16/7/971

Internet

https://www.mdpi.com/1424-8247/16/7/971

Similar Items