ShK‐modified UCMSCs Inhibit M1‐Like Macrophage Polarization and Alleviate Osteoarthritis Progression via PI3K/Akt Axis

ShK‐modified UCMSCs Inhibit M1‐Like Macrophage Polarization and Alleviate Osteoarthritis Progression via PI3K/Akt Axis

Abstract The potassium channel Kv1.3 plays an important role in regulating immune cell functions in many inflammatory diseases whereas rarely in osteoarthritis (OA). Here, it is demonstrated that the Kv1.3 of macrophages is upregulated in response to LPS stimulation, as well as in human OA synovium...

Full description

Bibliographic Details
Main Authors: Wenshu Wu, Xueying An, Wang Gong, Lin Yang, Na Liu, Bin Liu, Baosheng Guo, Qing Jiang, Lan Li
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
Kv1.3
Macrophage
Osteoarthritis
UCMSC
Online Access:https://doi.org/10.1002/advs.202406822

Internet

https://doi.org/10.1002/advs.202406822

Similar Items