Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma
Germinal center lymphoma is a heterogeneous human lymphoma entity. Here we report that constitutive activity of SHP2 (PTPN11) and its downstream kinase ERK is essential for the viability of germinal center lymphoma cells and disease progression. Mechanistically, SHP2/ERK inhibition impedes c-Myc tra...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Sprog: | English |
| Udgivet: |
Ferrata Storti Foundation
2014-12-01
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| Serier: | Haematologica |
| Online adgang: | https://haematologica.org/article/view/7224 |