Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice

Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice

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Sickle cell disease (SCD) is an inherited blood disorder caused by a mutation in the HBB gene leading to hemoglobin S production and polymerization under hypoxia conditions leading to vaso-occlusion, chronic hemolysis, and progressive organ damage. This disease affects ~100,000 people in the United...

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Bibliographic Details
Main Authors: Nicole H. Lopez, Biaoru Li, Chithra Palani, Umapathy Siddaramappa, Mayuko Takezaki, Hongyan Xu, Wenbo Zhi, Betty S. Pace
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154101/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154101/?tool=EBI

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