The Ambivalence of Connexin43 Gap Peptides in Cardioprotection of the Isolated Heart against Ischemic Injury

The Ambivalence of Connexin43 Gap Peptides in Cardioprotection of the Isolated Heart against Ischemic Injury

The present study investigates infarct-reducing effects of blocking ischemia-induced opening of connexin43 hemichannels using peptides Gap19, Gap26 or Gap27. Cardioprotection by ischemic preconditioning (IPC) and Gap peptides was compared, and combined treatment was tested in isolated, perfused male...

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Bibliographic Details
Main Authors: Aleksander Tank Falck, Bjarte Aarmo Lund, David Johansen, Trine Lund, Kirsti Ytrehus
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
cardioprotection
connexin43
Gap peptides
ischemic preconditioning
mitochondrial respiration
heart
Online Access:https://www.mdpi.com/1422-0067/23/17/10197

Internet

https://www.mdpi.com/1422-0067/23/17/10197

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