Integrative Analysis of Germline Rare Variants in Clear and Non–clear Cell Renal Cell Carcinoma

Integrative Analysis of Germline Rare Variants in Clear and Non–clear Cell Renal Cell Carcinoma

Background and objective: Previous germline studies on renal cell carcinoma (RCC) have usually pooled clear and non–clear cell RCCs and have not adequately accounted for population stratification, which might have led to an inaccurate estimation of genetic risk. Here, we aim to analyze the major ger...

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Bibliographic Details
Main Authors: Seung Hun Han, Sabrina Y. Camp, Hoyin Chu, Ryan Collins, Riaz Gillani, Jihye Park, Ziad Bakouny, Cora A. Ricker, Brendan Reardon, Nicholas Moore, Eric Kofman, Chris Labaki, David Braun, Toni K. Choueiri, Saud H. AlDubayan, Eliezer M. Van Allen
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:European Urology Open Science
Subjects:
Renal cell carcinoma
Population stratification
Germline pathogenic variants
Cryptic splice variant
Copy number variant
CHEK2-associated cancer risk
Online Access:http://www.sciencedirect.com/science/article/pii/S2666168324002635

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http://www.sciencedirect.com/science/article/pii/S2666168324002635

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