A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins

A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins

E3 ligases constitute a large and diverse family of proteins that play a central role in regulating protein homeostasis by recruiting substrate proteins via recruitment domains to the proteasomal degradation machinery. Small molecules can either inhibit, modulate or hijack E3 function. The latter cl...

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Bibliographic Details
Main Authors: Martin P. Schwalm, Lena M. Berger, Maximilian N. Meuter, James D. Vasta, Cesear R. Corona, Sandra Röhm, Benedict-Tilman Berger, Frederic Farges, Sebastian M. Beinert, Franziska Preuss, Viktoria Morasch, Vladimir V. Rogov, Sebastian Mathea, Krishna Saxena, Matthew B. Robers, Susanne Müller, Stefan Knapp
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
IAP
E3 Ligase
PROTAC
Ubiquitin
NanoBRET
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.886537/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.886537/full

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