Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes

Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes

Cycloisomerization of 1,n-allenynes allows to efficiently assembly polycyclic skeletons, however its asymmetric variant remains elusive. Here, the authors report the enantioselective Rh(I)-catalyzed cycloisomerization of 1,6-allenynes and disclose an uncommon 5-exo-dig pathway via DFT calculations.

Bibliographic Details
Main Authors: Xu Deng, Li-Yang Shi, Jialing Lan, Yu-Qing Guan, Xiaoyong Zhang, Hui Lv, Lung Wa Chung, Xumu Zhang
Format: Article
Language:English
Published: Nature Portfolio 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08900-z

Internet

https://doi.org/10.1038/s41467-019-08900-z

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