Poloxamer 407 Induces Hypertriglyceridemia but Decreases Atherosclerosis in Ldlr<sup>−/−</sup> Mice

Poloxamer 407 Induces Hypertriglyceridemia but Decreases Atherosclerosis in Ldlr<sup>−/−</sup> Mice

Background: Hypertriglyceridemia (HTG) increases the risk for atherosclerotic cardiovascular disease, but underlying mechanisms are incompletely understood. Circulating monocytes play an important role in atherogenesis by infiltrating arterial walls, where they differentiate into macrophages. We tes...

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Bibliographic Details
Main Authors: Xueying Peng, Zeqin Lian, Xiao-Yuan Dai Perrard, Yunjie Xiao, Jing Ni, Veronica O’Brien, Henry Dong, Henry J. Pownall, Christie M. Ballantyne, Huaizhu Wu
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
poloxamer 407
atherogenesis
hypertriglyceridemia
foamy monocytes
lipid metabolism
monocyte phenotype
Online Access:https://www.mdpi.com/2073-4409/11/11/1795

Internet

https://www.mdpi.com/2073-4409/11/11/1795

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