The Glioblastoma Microenvironment: Morphology, Metabolism, and Molecular Signature of Glial Dynamics to Discover Metabolic Rewiring Sequence

The Glioblastoma Microenvironment: Morphology, Metabolism, and Molecular Signature of Glial Dynamics to Discover Metabolic Rewiring Sequence

Different functional states determine glioblastoma (GBM) heterogeneity. Brain cancer cells coexist with the glial cells in a functional syncytium based on a continuous metabolic rewiring. However, standard glioma therapies do not account for the effects of the glial cells within the tumor microenvir...

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Bibliographic Details
Main Authors: Assunta Virtuoso, Roberto Giovannoni, Ciro De Luca, Francesca Gargano, Michele Cerasuolo, Nicola Maggio, Marialuisa Lavitrano, Michele Papa
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
microglia
astrocytes
high-grade glioma
cross-talk
hypoxia
metabolism
Online Access:https://www.mdpi.com/1422-0067/22/7/3301

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https://www.mdpi.com/1422-0067/22/7/3301

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