iPSC-sEVs alleviate microglia senescence to protect against ischemic stroke in aged mice

iPSC-sEVs alleviate microglia senescence to protect against ischemic stroke in aged mice

The polarization of microglia plays an important role in the outcome of ischemic stroke (IS). In the aged population, senescent microglia show a predominant pro-inflammatory phenotype, which leads to worse outcomes in aged ischemic stroke compared to young ischemic stroke. Recent research demonstrat...

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Bibliographic Details
Main Authors: Xinyu Niu, Yuguo Xia, Lei Luo, Yu Chen, Ji Yuan, Juntao Zhang, Xianyou Zheng, Qing Li, Zhifeng Deng, Yang Wang
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Materials Today Bio
Subjects:
Induced pluripotent stem cell-derived small extracellular vesicles (iPSC-sEVs)
Senescent microglia
Ischemic stroke
Aging
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006423000601

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http://www.sciencedirect.com/science/article/pii/S2590006423000601

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