Niraparib Suppresses Cholangiocarcinoma Tumor Growth by Inducing Oxidative and Replication Stress

Niraparib Suppresses Cholangiocarcinoma Tumor Growth by Inducing Oxidative and Replication Stress

Cholangiocarcinoma (CCA) is the second most common hepatobiliary cancer, an aggressive malignancy with limited therapeutic options. PARP (poly (ADP-ribose) polymerase) 1 and 2 are important for deoxyribonucleotide acid (DNA) repair and maintenance of genomic stability. PARP inhibitors (PARPi) such a...

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Bibliographic Details
Main Authors: Vladimir Bezrookove, John M. Patino, Mehdi Nosrati, Pierre-Yves Desprez, Sean McAllister, Liliana Soroceanu, Ari Baron, Robert Osorio, Mohammed Kashani-Sabet, Altaf A. Dar
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
cholangiocarcinoma
PAPR inhibitors
patient derived xenograft
oxidative stress
replication fork stalling
Online Access:https://www.mdpi.com/2072-6694/13/17/4405

Internet

https://www.mdpi.com/2072-6694/13/17/4405

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