Dose fractionation of CAR-T cells. A systematic review of clinical outcomes

Abstract CAR-T cells are widely recognized for their potential to successfully treat hematologic cancers and provide durable response. However, severe adverse events such as cytokine release syndrome (CRS) and neurotoxicity are concerning. Our goal is to assess CAR-T cell clinical trial publications...

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Bibliographic Details
Main Authors: Matthew Frigault, Anand Rotte, Ayub Ansari, Bradford Gliner, Christopher Heery, Bijal Shah
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Online Access:https://doi.org/10.1186/s13046-022-02540-w