Venetoclax durable response in adult relapsed/refractory Philadelphia-negative acute lymphoblastic leukemia with JAK/STAT pathway alterations

Venetoclax durable response in adult relapsed/refractory Philadelphia-negative acute lymphoblastic leukemia with JAK/STAT pathway alterations

High-risk relapsed/refractory adult Philadelphia-negative (Ph−) B-cell acute lymphoblastic leukemia (B-ALL) is a great challenge due to limited possibilities to achieve and maintain a complete response. This also applies to cases with extramedullary (EM) involvement that have poor outcomes and no ac...

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Bibliographic Details
Main Authors: Anna Ferrari, Delia Cangini, Andrea Ghelli Luserna di Rorà, Annalisa Condorelli, Marta Pugliese, Giovanni Schininà, Sebastiano Cosentino, Eugenio Fonzi, Chiara Domizio, Giorgia Simonetti, Salvatore Leotta, Giuseppe Milone, Giovanni Martinelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
acute lymphoblastic leukemia
venetoclax (BCL-2 inhibitor)
Philadelphia-negative cells
JAK/STAT
extramedullary
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1165308/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1165308/full

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