Identification of a potent dual-function inhibitor for hIMPDH isoforms by computer-aided drug discovery approaches

Identification of a potent dual-function inhibitor for hIMPDH isoforms by computer-aided drug discovery approaches

Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in de novo biosynthesis of purine nucleotides. Due to this important role, it is a great target to drug discovery for a wide range of activities, especially immunosuppressant in heart and kidney transplantation. Both human IMPDH isoforms ar...

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Bibliographic Details
Main Authors: Meysam Yazdani, Javad Zamani, Seyed Safa-Ali Fatemi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
drug discovery
hIMPDH
immunosuppressant
virtual screening
transplant rejection
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.977568/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.977568/full

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