TP53 and p21 (CDKN1A) polymorphisms and the risk of systemic lupus erythematosus

TP53 and p21 (CDKN1A) polymorphisms and the risk of systemic lupus erythematosus

Abstract Background The p53 and p21 proteins are important regulators of cell cycle and apoptosis and may contribute to autoimmune diseases, such as systemic lupus erythematosus (SLE). As genetic polymorphisms may cause changes in protein levels and functions, we investigated associations of TP53 an...

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Bibliographic Details
Main Authors: Jacyara Maria Brito Macedo, Amanda Lima Silva, Amanda Chaves Pinto, Leandro Ferreira Lopes Landeira, Elyzabeth Avvad Portari, Cintia Barros Santos-Rebouças, Evandro Mendes Klumb
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Advances in Rheumatology
Subjects:
Systemic lupus erythematosus
Genetic polymorphisms
TP53
p21
Online Access:https://doi.org/10.1186/s42358-023-00320-4

Internet

https://doi.org/10.1186/s42358-023-00320-4

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