SuperDendrix algorithm integrates genetic dependencies and genomic alterations across pathways and cancer types

SuperDendrix algorithm integrates genetic dependencies and genomic alterations across pathways and cancer types

Summary: Recent genome-wide CRISPR-Cas9 loss-of-function screens have identified genetic dependencies across many cancer cell lines. Associations between these dependencies and genomic alterations in the same cell lines reveal phenomena such as oncogene addiction and synthetic lethality. However, co...

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Bibliographic Details
Main Authors: Tae Yoon Park, Mark D.M. Leiserson, Gunnar W. Klau, Benjamin J. Raphael
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Cell Genomics
Subjects:
CRISPR screen
essential genes
genetic dependency
mutual exclusivity
oncogene addiction
oncogenic pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X22000167

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http://www.sciencedirect.com/science/article/pii/S2666979X22000167

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