Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses

Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses

In this work, the authors report that hyperphosphorylated recombinant tau spontaneously assembles into small, amorphous aggregates, which disrupt membranes and induce Toll-like receptor 4-dependent responses in human macrophages.

Bibliographic Details
Main Authors: Jonathan X. Meng, Yu Zhang, Dominik Saman, Arshad M. Haider, Suman De, Jason C. Sang, Karen Brown, Kun Jiang, Jane Humphrey, Linda Julian, Eric Hidari, Steven F. Lee, Gabriel Balmus, R. Andres Floto, Clare E. Bryant, Justin L. P. Benesch, Yu Ye, David Klenerman
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30461-x

Internet

https://doi.org/10.1038/s41467-022-30461-x

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