Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses
In this work, the authors report that hyperphosphorylated recombinant tau spontaneously assembles into small, amorphous aggregates, which disrupt membranes and induce Toll-like receptor 4-dependent responses in human macrophages.
Main Authors: | , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-05-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-30461-x |