Platelet-derived growth factor-BB and white matter hyperintensity burden in APOE4 carriers

Background: The apolipoprotein-e4 (APOE4) gene increases risk for developing late-onset Alzheimer's disease (AD) and has been linked to increased microvascular dysfunction, including pericyte degeneration and blood-brain barrier breakdown. Platelet-derived growth factor-BB (PDGF-BB) is a glycop...

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Bibliographic Details
Main Authors: Arunima Kapoor, Daniel A Nation
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cerebral Circulation - Cognition and Behavior
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666245022000964