Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders
Abstract Heart failure, the leading cause of mortality and morbidity in the developed world, is characterized by cardiac ryanodine receptor 2 channels that are hyperphosphorylated, oxidized, and depleted of the stabilizing subunit calstabin-2. This results in a diastolic sarcoplasmic reticulum Ca2+...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-51791-y |