Synthetic Derivatives of Natural <i>ent</i>-Kaurane Atractyligenin Disclose Anticancer Properties in Colon Cancer Cells, Triggering Apoptotic Cell Demise

Synthetic Derivatives of Natural <i>ent</i>-Kaurane Atractyligenin Disclose Anticancer Properties in Colon Cancer Cells, Triggering Apoptotic Cell Demise

The antitumor activity of different <i>ent</i>-kaurane diterpenes has been extensively studied. Several investigations have demonstrated the excellent antitumor activity of synthetic derivatives of the diterpene atractyligenin. In this research, a series of new synthetic amides and their...

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Bibliographic Details
Main Authors: Natale Badalamenti, Antonella Maggio, Gianfranco Fontana, Maurizio Bruno, Marianna Lauricella, Antonella D’Anneo
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
atractyligenin derivatives
apoptotic cell death
chromatin fragmentation
Poly [ADP-ribose] polymerase 1
HCT116
Caco-2
Online Access:https://www.mdpi.com/1422-0067/25/7/3925

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https://www.mdpi.com/1422-0067/25/7/3925

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