Emergence of mcr-9.1 in Extended-Spectrum-β-Lactamase-Producing Clinical Enterobacteriaceae in Pretoria, South Africa: Global Evolutionary Phylogenomics, Resistome, and Mobilome

Emergence of mcr-9.1 in Extended-Spectrum-β-Lactamase-Producing Clinical Enterobacteriaceae in Pretoria, South Africa: Global Evolutionary Phylogenomics, Resistome, and Mobilome

ABSTRACT Extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae are critical-priority pathogens that cause substantial fatalities. With the emergence of mobile mcr genes mediating resistance to colistin in Enterobacteriaceae, clinicians are now left with few therapeutic options. Eleven cl...

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Bibliographic Details
Main Authors: John Osei Sekyere, Nontuthuko E. Maningi, Lesedi Modipane, Nontombi Marylucy Mbelle
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mSystems
Subjects:
ESBLs
Enterobacteriaceae
mcr-9.1
South Africa
critical pathogens
colistin resistance
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00148-20

Internet

https://journals.asm.org/doi/10.1128/mSystems.00148-20

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